Journal of Molecular Catalysis A-Chemical, Vol.195, No.1-2, 95-100, 2003
Transfer hydrogenation of a variety of ketones catalyzed by rhodium complexes in aqueous solution and their application to asymmetric reduction using chiral Schiff base ligands
The rhodium complex [Cp*Rh(bpy)Cl]Cl shows efficient catalytic activity in the transfer hydrogenation of a wide variety of ketones in aqueous formic acid solution under mild reaction conditions. In the asymmetric reduction using chiral Schiff base ligands, the asymmetric induction was observed in reduction of dialkyl ketones as well as aryl ketones, among which ortho-chloroacetophenone gave the highest ee of 84%. (C) 2002 Elsevier Science B.V. All rights reserved.
Keywords:transfer hydrogenation;asymmetric reduction;rhodium complex;aqueous reaction;chiral ligand;ketones