Journal of Molecular Catalysis A-Chemical, Vol.219, No.2, 315-317, 2004
Experimental and theoretical investigation of the relationship between the stericstructure of Schiff bases and the diastereo selectivity of pinacol produced from benzaldehyde
After synthesis of a series of chiral Schiff bases from easily available amino-alcohol, pinacol coupling reaction of benzaldehyde catalyzed by a series of Schiff bases-Ti complexes afforded pinacol with high yield and different diastereoselectivity. The relationship between the stericstructure of these Schiff bases and the diastereoselectivity of pinacol was systemically studied and calculated by QSAR calculation method. (C) 2004 Elsevier B.V. All rights reserved.