Journal of Molecular Catalysis A-Chemical, Vol.250, No.1-2, 6-8, 2006
MgBr2 center dot OEt2 mediated protection of alcohols with hexamethyldisilazane: An efficient catalytic route for the preparation of silyl ethers under solvent-free conditions
Various types of alcohols and phenols were rapidly protected by hexamethyldisilazane in good to excellent yields at room temperature in the presence of catalytic amount of magnesium bromide ethyl etherate under solvent-free conditions. Good to excellent chemoselectivity was demonstrated for competitive protection of primary hydroxyls in the presence of secondary and tertiary alcohols. Highly selective protection of phenols in the presence of aromatic amines was also demonstrated successfully. (c) 2006 Elsevier B.V. All rights reserved.