Journal of Molecular Catalysis A-Chemical, Vol.254, No.1-2, 68-77, 2006
Alkene- and alkyne-bridged mimics of nisin as potential peptide-based antibiotics
Here we highlight our recent results of the application of ring-closing metathesis and ring-closing alkyne metathesis (RCAM) in biologically relevant biomolecules in order to introduce alkene- and/or alkyne-bridges as novel covalent constraints for stabilizing their bioactive conformation and increasing their metabolic stability. (c) 2006 Elsevier B.V. All rights reserved.
Keywords:ring-closing alkene metathesis;ring-closing alkyne metathesis;peptidomimetics;peptide-based antibiotics