Journal of Molecular Catalysis A-Chemical, Vol.256, No.1-2, 99-105, 2006
Silica supported fluoroboric acid as a novel, efficient and reusable catalyst for the synthesis of 1,5-benzodiazepines under solvent-free conditions
An efficient synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones under solvent-free conditions in the presence of a catalytic amount of HBF4-SiO2 is discussed. Cyclic and acyclic ketones reacted smoothly to furnish high yield of the products with selectivity in short reaction time. (c) 2006 Elsevier B.V All rights reserved.