Journal of Molecular Catalysis A-Chemical, Vol.259, No.1-2, 116-120, 2006
Efficient catalytic synthesis of optically pure 1,2-azido alcohols through enantioselective epoxide ring opening with HN3
Chiral binuclear Co(salen) complexes bearing Lewis acid of group 13 metal chlorides show very high catalytic activity and enantioselectivity for the ring opening of epoxides using HN3 as azide source. It provides a facile and practical synthetic route to a wide range of chiral nonracemic 1,2-azido alcohols and related compounds in one-pot synthesis with excellent selectivity (92.0-99.6% e.e.) under mild conditions. The presence of Lewis acid of group 13 shows a strong synergistic effect. (c) 2006 Elsevier B.V. All rights reserved.
Keywords:asymmetric catalysis;heterometallic chiral salen complexes;1,2-azido alcohols;1,2-amino alcohols