A simple and economical chemical neutralization method is developed against highly toxic chemical warfare agent's viz. sulfur mustard (SM), sesquimustard, and their homologues/analogous. The method involves treatment of chemical warfare agents with sodium in inert solvents. This destruction method of sulfur mustards release innocuous products via desulfurization reactions. The products were characterized by GC-MS technique. The method is suitable in particular, for bulk destruction of heel of mustard stockpiles. (c) 2006 Elsevier B.V. All rights reserved.