The colorimetric difference between pairs of observers is simulated by a proper filtering of the stimulating radiation, and their comparison is made on properly defined Common Reference Frames in the tristimulus space. As examples, two comparisons are proposed: (1) Comparison between the Vos modification of the CIE 1931 Standard Colorimetric Observer and the CIE 1964 Supplementary Standard Observer: in this case, it is supposed that the difference between these two color-vision systems is due to the macula lutea only, which with a spectral selective absorbance alters the power spectral distribution of the color stimuli. The optical density of the macular pigment is well reproduced. (2) Comparison between the Vos modification of the CIE 1931 Standard Colorimetric Observer and the CIE 1931 Standard Colorimetric Observer: in this case, the difference between these two observers could be simulated by different calibration of the photodetectors.