We have investigated the initial growth of MnSb and MnAs films and multilayers on GaAs(1 0 0) and (1 1 1)B substrates by molecular beam epitaxy (MBE) and successfully grown epitaxial MnSb/MnAs multilayers on GaAs(1 1 1)B. We propose a possibility of the novel heat-induced giant magnetoresistance (GMR) effect in the MnSb/MnAs multilayer system.