This paper considers the temperature control of semi-batch polymerization reactors in which some of the following issues must be considered : (i) production of multiple products in the same reactor; (ii) changing heat transfer characteristics, during a batch and from batch to batch; (iii) time varying and nonlinear reaction rate due to changing monomer concentration and diffusion controlled termination reactions (gel effect); (iv) the absence of detailed kinetic models for the reactors. The industrial challenge problem published by Chylla and Haase [Chylla, R. W. and Haase, D. R. (1993) Temperature control of semi-batch polymerization reactors (with corrected updates). Comput. Chem. Eng. 17, 257-264) is used as the simulation basis for evaluating these problems.A nonlinear adaptive controller consisting of a nonlinear controller (based on differential geometric concepts) coupled with an extended Kalman filter (which uses only readily available data and knowledge) is shown to provide excellent control in all the above situations. In particular, the on-line estimation is critical for the strong performance of the nonlinear controller over a broad range of conditions. PID controllers with feedforward terms can perform well at one set of conditions, however, they require retuning as conditions and products change.