Fluoropolymer surfaces with new and specific functionalities, such as metal-free the intelligent choice of functional monomers for graft copolymerization on pre-activated biocompatability, and bondability to metals, can be obtained through activated fluoropolymer surfaces, as highlighted in this review. The Figure shows a gold/fluoropolymer laminate held together by crosslinked glycidyl methacrylate polymer grafted on both surfaces.