The present paper describes materials of polypeptide-commodity polymer hybrids from poly(vinyl alcohol) (PVA) and poly(sodium alpha,beta-D,L-aspartate) (1). Miscible blend films of polypeptide 1 and PVA were prepared by the solvent-cast method from a homogeneous aqueous solution. Differential scanning calorimetry, Fourier transform infrared, and scanning electron microscopy combined with energy dispersive X-ray spectroscopy (EDX) were used to investigate the blends. It was revealed that 1 and PVA are miscible in a wide range of compositions.