The O-phospho-L-serine [Ser(P)] containing peptides and proteins play an important role in controlling the morphology of biominerals. The poly[Ser(P)] and copoly[Ser(P)(x)Asp(y)] affect the calcium carbonate (CaCO3) morphology and polymorph. The CaCO3 helical structures were obtained in the presence of copoly[Ser(P)(75)Asp(25)]. When the L-copolymer was used as an additive, a clockwise P twisted spiral morphology was formed. On the other hand, when using D-copolymer, a counterclockwise M twisted spiral morphology was obtained.