Water resources used for drinking water production are more and more contaminated by Volatile Organic Compounds (VOCs), particularly by halogenated VOCs (HOVs), like chloroform, trichloroethylene (TCE) and tetrachloroethylene, because of industrial pollution. At the same time new regulations and guidelines on drinking water quality are more stringent on toxic agents, especially on HOVs. Among the different membrane processes, Vacuum Membrane Distillation (VMD) seems to be a promising one. The present paper aims to evaluate if VMD could be used to remove HOVs at very low concentration from water from experimental results obtained with synthetic waters. It also deals with a characterisation of the influence of some process parameters on flux and selectivity according to two different approaches: experiments and simulation. Influence of temperature and downstream pressure on the process productivity is discussed in terms of selectivity which characterises the permeate concentration but also of equivalent flux of treated water which is here the concentrate. As quite high equivalent fluxes can be expected VMD appears as a promising way to remove TCE and other HOVs from water at a low concentration.