Diblock terpolymers, that consist of homopolymer and statistical copolymer (polyampholyte) building blocks are synthesized by group transfer polymerization. Two types of block tepolymers are explored in aqueous media: the amphiphilic poly{[(diethylamino)ethyl methacrylatel-co-(methacrylic acid))-block-poly(methyl methacrylate) and the double hydrophilic poly [oligo(ethylene glycol) methacrylatel-block-poly{[(diethylamino)ethyl methacrylatel-co-(methacrylic acid)}. The first terpolymer self-assembles in aqueous media to form responsive micelles that change their corona charge sign upon switching pH. The second terpolymer exhibits a multi-responsive behavior. It forms neutral, positive, or negative micelles depending on a combination of different environmental conditions such as temperature, pH, and ionic strength.