Microwave heating is becoming a widely accepted tool for synthetic chemists. While many reactions have been performed on a small scale using microwave heating, few have been further developed into larger-scale syntheses. Here, a microwave-promoted esterification reaction protocol is presented. The apparatus used allows for the removal of water generated during the course of the reaction and as a result the process can be driven toward completion. Reactions have been run on scales up to 3 mol.