Chitosan-g-Poly(2-Hydroxyethyl Methacrylate) 그라프트 공중합체막의 생체적합성

김공수; 조석형; 전용철; 신재섭; 김경호; 임정수

Polymer(Korea), Vol.14, No.4, 385-391, August, 1990

Export Citation

Chitosan-g-Poly(2-Hydroxyethyl Methacrylate) 그라프트 공중합체막의 생체적합성

Biocompatibility of Chitosan-g-Poly(2-Hydroxyethyl Metacrylate) Membranes

김공수, 조석형, 전용철, 신재섭, 김경호, 임정수

초록

chitosan-poly(2-hydroxyethyl methacrylate) 그라프트 공중합체를 막으로 제조하고 그 막을 아세틸화 한 후 인공피부로서의 사용가능성을 검토하기 위하여 흡수성, 기계적 성질, 수증기 및 산소 투과성, 효소에 의한 생분해성등을 검토하였다. 흡수성은 130∼460%였고 기계적 강도는 242∼506 kg/㎠으로서 정상피부 보다 높은 값을 보였으며, 수증기 및 산소 투과성은 7.4×10^-9∼3.4×10^-8(g·cm·cm^-2s^-l)과 1.4×10^-8∼3.17×l0^-7 (cm³(STP) cm·cm^-2s^-l·cmHg^-l)이었다. 효소에 의한 생분해성은 9∼10일 까지는 빠르게 증가하였으나 그 이 후는 거의 증가하지 않았다.

The membranes of acetylated chitosan-g-poly (2-hydroxyethyl methacrylate) were prepared for a skin substitute, and water content, tensile strength, elongation, permeability of water vapor and oxygen, and biodegradability of the membrane was determined. The water absorption was 130∼460%, and the tensile strength(242∼506 kg/cm²) was higher than that of the normal skin. The coefficients of water vapor and oxygen permeability were 7.4×10^-9∼3.4×10^-8(g·cm·cm^-2s^-1) and 1.4×10^-8∼3.17×10^-7(cm³(STP)cm·cm^-2s^-1cmHg^-1), respectively. The biodegradation rate was fast at the initial state, but it became slower after 9∼10 days.

[References]

Hall CW, Spira M, Gerow F, Adams L, Martin E, Hardy SB, Trans. Am. Soc. Artif. Intern. Organs., 16 (1977)
Capozza RC, Enzymically Decomposable Biodegradable Pharmaceutical Carrier, Ger. Pat., 2, 505, 305 (1975)
Wistler RJ, Kosik M, Arch. Biochem. Biopolym., 142, 106 (1971)
Kojima K, Iguchi S, Kajima Y, Yoshikumi M, J. Appl. Polym. Sci., 28, 87 (1983)
Bloch R, Burger MM, Biochem. Biophys. Res. Commun., 58, 13 (1974)
Bough WA, Food Product Develop., 11, 90 (1977)
Muzzarelli RAA, "Chitin," Pergamon Press Ltd., p. 257 (1977)
Creighton CP, Teschemacher CR, U.S. Patent, 4,109,074 (1978)
Nathan P, Law EJ, Macmillan BG, Murphy DF, Ronel SH, Andrade JD, Abrhans RA, Trans. Am. Soc. Artif. Int. Organs., XXII, 30 (1986)
Tollar M, Stol M, Kliment K, J. Biomed. Mater. Res., 3, 305 (1969)
Lee PI, J. Control. Release, 4, 1 (1986)
Cho SH, Kim KS, Kim KH, Shin JS, Polym.(Korea), 14(1), 9 (1990)
Aiba SI, Minoura N, Fujiwara Y, Kobunshi Ronbunshu, 36, 299 (1982)
Aiba S, Minoura N, Fujiwara Y, Kobunshi Ronbunshu, 39, 299 (1982)
Kim JH, Kim KY, Polym.(Korea), 8(2), 98 (1984)
Homsy CA, J. Biomed. Mater. Res., 4, 341 (1970)
Tokura S, Nishi N, Nishimura S, Sonorin O, Sen-I Gakkaishi, 39, 45 (1983)
Balassa LL, Prudden JF, Proc. 1st International Conference Chitin/Chitosan, MIT, p. 296 (1977)

[Referenced By]

[1] Hall CW, Spira M, Gerow F, Adams L, Martin E, Hardy SB, Trans. Am. Soc. Artif. Intern. Organs., 16 (1977)

[2] Capozza RC, Enzymically Decomposable Biodegradable Pharmaceutical Carrier, Ger. Pat., 2, 505, 305 (1975)

[3] Wistler RJ, Kosik M, Arch. Biochem. Biopolym., 142, 106 (1971)

[4] Kojima K, Iguchi S, Kajima Y, Yoshikumi M, J. Appl. Polym. Sci., 28, 87 (1983)

[5] Bloch R, Burger MM, Biochem. Biophys. Res. Commun., 58, 13 (1974)

[6] Bough WA, Food Product Develop., 11, 90 (1977)

[7] Muzzarelli RAA, "Chitin," Pergamon Press Ltd., p. 257 (1977)

[8] Creighton CP, Teschemacher CR, U.S. Patent, 4,109,074 (1978)

[9] Nathan P, Law EJ, Macmillan BG, Murphy DF, Ronel SH, Andrade JD, Abrhans RA, Trans. Am. Soc. Artif. Int. Organs., XXII, 30 (1986)

[10] Tollar M, Stol M, Kliment K, J. Biomed. Mater. Res., 3, 305 (1969)

[11] Lee PI, J. Control. Release, 4, 1 (1986)

[12] Cho SH, Kim KS, Kim KH, Shin JS, Polym.(Korea), 14(1), 9 (1990)

[13] Aiba SI, Minoura N, Fujiwara Y, Kobunshi Ronbunshu, 36, 299 (1982)

[14] Aiba S, Minoura N, Fujiwara Y, Kobunshi Ronbunshu, 39, 299 (1982)

[15] Kim JH, Kim KY, Polym.(Korea), 8(2), 98 (1984)

[16] Homsy CA, J. Biomed. Mater. Res., 4, 341 (1970)

[17] Tokura S, Nishi N, Nishimura S, Sonorin O, Sen-I Gakkaishi, 39, 45 (1983)

[18] Balassa LL, Prudden JF, Proc. 1st International Conference Chitin/Chitosan, MIT, p. 296 (1977)