We have utilised genomic and EST databases to assemble the sequence of the human talin2( TLN2) gene. Talin2 protein is similar in size and sequence to talin1 throughout its length (74% identity, 86% similarity). The major differences are in (i) the size of the genes, the TLN2 gene is >200 kb compared with similar to 30 kb for TLN1 due to a difference in intron size, although intron/exon boundaries, with the exception of two, are strictly conserved; (ii) the expression patterns, TLN1 gives rise to an similar to8-kb mRNA which is observed in all tissues, whereas MAT gives rise to multiple transcripts with the highest levels in heart.