The fate of the prion protein in the prion/plasminogen complex

Kornblatt JA; Marchal S; Rezaei H; Kornblatt MJ; Balny C; Lange R; Debey MP; Hoa GHB; Marden MC; Grosclaude J

Biochemical and Biophysical Research Communications, Vol.305, No.3, 518-522, 2003

DOI10.1016/S0006-291X(03)00804-0 Export Citation

The fate of the prion protein in the prion/plasminogen complex

Kornblatt JA, Marchal S, Rezaei H, Kornblatt MJ, Balny C, Lange R, Debey MP, Hoa GHB, Marden MC, Grosclaude J

The cellular prion protein (PrPc) forms complexes with plasminogen. Here, we show that the PrPc in this complex is cleaved to yield fragments of PrPc. The cleavage is accelerated by plasmin but does not appear to be dependent on it. (C) 2003 Elsevier Science (USA). All rights reserved.

Keywords:plasminogen;prion protein;prion cleavage