Various quaternary chitosan derivative structures were synthesized by reacting N-chloroacyl-6-O-triphenylmethy-1-chitosans with tertiary an-tines. Full substitutions were obtained from the quaternization reactions and the obtained water-soluble quaternary chitosan derivatives were thoroughly characterized with H-1 NMR, C-13 NMR, H-1-C-13 HSQC NMR, and FT-IR.