Poly(2-hydorxyethylmethacrylate)를 포함한 공중합체 수화겔막에 대한 아미드의 투과특성

박유미; 김은식; 성용길

Polymer(Korea), Vol.15, No.3, 356-363, June, 1991

Transport Characteristics of Amide Solutes through Copolymer Hydrogel Membranes Containing Poly(2- hydroxyethylmethacrylate)

박유미, 김은식, 성용길

초록

용매 존재하에서 2-hydroxyethylmethacrylate와 acrylamide, N,N-dimethylacrylamide 및 methylmethacrylate의 함량을 바꾸어가며 세 종류의 공중합체 수화겔막들을 제조하였다. 이들 막에 대한 아미드류의 투과 및 분배계수를 측정하였으며, 이 측정값들을 이용하여 아미드의 투과메카니즘을 논의하였다. 수화겔막에서 용질의 분배는 주로 막과 용질 사이의 소수성 상호작용에 의해 조절되었다. 용질의 확산은 bulk 및 bound water 양쪽 모두에서 일어나며, bulk water 보다는 bound water에서 더 빨리 일어남을 알 수 있었다. 그리고 bound water 내에서 용질 확산 정도는 막 내의 물과 용질 사이의 친수성 결합에 의해 조절되었다. Urea는 고분자쇄와 상호작용하지 않으며, urea의 분배계수는 막의 종류에 무관하며, 막의 물함량에만 의존하였다. 그리고 urea의 특이한 투과성은 bound water와 urea 사이의 높은 수소결합력에 기인함을 알 수 있었다.

Three kinds of hydrogel membranes were prepared by the copolymerization of 2-hydroxyethylmethacrylate(HEMA) with acrylamide, N,N-dimethylacrylamide and methylmethacrylate in the presence of solvent and crosslinker, respectively. The equilibrium water content, relative permeability and partition coefficient of the membranes for amide solutes were measured. It has been found that in the hydrogel membrane, the partition of solute was controlled by the hydrophobic interaction of solute-membrane, and the diffusion of solute occurs in both bound water and bulk water. The transport of solute more rapidly occurs in bound water than bulk water. And in the bound water, the diffusions of solutes were controlled by the hydrophilic bonding of solute-bound water. Also we knew that urea is not interacted with the polymer network, its partition coefficient depends on the water content of membrane, and the highly transport of urea depends on hydrogen bonding ability between urea and bound water.

[References]

Jadwin TA, Hoffman AS, Vieth WR, J. Appl. Polym. Sci., 14, 1339 (1970)
Ratner BD, Miller IF, J. Polym. Sci. A: Polym. Chem., 10, 2425 (1972)
Ratner ED, Miller IF, J. Biomed. Mater. Res., 7, 353 (1973)
Lee KH, Lee JG, Jhon MS, Lee TK, J. Bioeng., 2, 269 (1987)
Wisniewski S, Kim SW, "Water in Polymers," ed. by S.P. Rowland, ACS Symposium Series, pp. 347-359 (1980)
Higuchi A, Ijima T, J. Appl. Polym. Sci., 32, 3229 (1986)
Lyman DJ, Annual Report, Contract NIH 70-2017, National Institute of Health (1971)
Mah MY, M.S. Thesis, University of Utah (1972)
Graig LC, Konigasberg W, J. Phys. Chem., 65, 166 (1961)
Wisniewski S, Kim SW, J. Membr. Sci., 6, 229 (1980)
Koo HS, Jhon MS, Bull. Korean Chem. Soc., 1, 138 (1980)
Ferry JD, J. Gen. Physiol., 20, 95 (1936)
Rankin EM, J. Gen. Physiol., 38, 225 (1954)
Higuchi A, Abe M, Comiyama J, Ijima T, J. Membr. Sci., 21, 113 (1984)
Higuchi A, Fishima M, Ijima T, J. Membr. Sci., 25, 171 (1985)
Toprak C, Agar JN, Faik M, J. Chem. Soc.-Faraday Trans., 75, 803 (1979)
Mackie JS, Meares P, Proc. Roy. Soc. London A, 232, 498 (1955)
Longsworth LG, J. Phys. Chem., 67, 689 (1963)

[Referenced By]

[1] Jadwin TA, Hoffman AS, Vieth WR, J. Appl. Polym. Sci., 14, 1339 (1970)

[2] Ratner BD, Miller IF, J. Polym. Sci. A: Polym. Chem., 10, 2425 (1972)

[3] Ratner ED, Miller IF, J. Biomed. Mater. Res., 7, 353 (1973)

[4] Lee KH, Lee JG, Jhon MS, Lee TK, J. Bioeng., 2, 269 (1987)

[5] Wisniewski S, Kim SW, "Water in Polymers," ed. by S.P. Rowland, ACS Symposium Series, pp. 347-359 (1980)

[6] Higuchi A, Ijima T, J. Appl. Polym. Sci., 32, 3229 (1986)

[7] Lyman DJ, Annual Report, Contract NIH 70-2017, National Institute of Health (1971)

[8] Mah MY, M.S. Thesis, University of Utah (1972)

[9] Graig LC, Konigasberg W, J. Phys. Chem., 65, 166 (1961)

[10] Wisniewski S, Kim SW, J. Membr. Sci., 6, 229 (1980)

[11] Koo HS, Jhon MS, Bull. Korean Chem. Soc., 1, 138 (1980)

[12] Ferry JD, J. Gen. Physiol., 20, 95 (1936)

[13] Rankin EM, J. Gen. Physiol., 38, 225 (1954)

[14] Higuchi A, Abe M, Comiyama J, Ijima T, J. Membr. Sci., 21, 113 (1984)

[15] Higuchi A, Fishima M, Ijima T, J. Membr. Sci., 25, 171 (1985)

[16] Toprak C, Agar JN, Faik M, J. Chem. Soc.-Faraday Trans., 75, 803 (1979)

[17] Mackie JS, Meares P, Proc. Roy. Soc. London A, 232, 498 (1955)

[18] Longsworth LG, J. Phys. Chem., 67, 689 (1963)