The adaptation of fatty acid composition of Chromohalobacter israelensis, a euryhalophilic bacterium, grown at different salt concentrations was studied. C. israelensis tolerated NaCl LIP to concentrations of 20% (w/v) and showed optimal growth at 7% (w/v). Major fatty acids of this bacterium,were palmitic acid (16:0), stearic acid (18:0), palmetoleic acid (16:1cis Delta 9), and cis-vaccenic acid (18:1 Delta 11).The salt concentration strongly influenced the fatty acid composition. In the presence of suboptimal salt concentrations, the degree of saturation decreased, suggesting the importance of salt in maintaining the osmotic balance of the cell with its environment.