Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Talukder KA; Khajanchi B; Islam M; Islam Z; Dutta DK; Rahman M; Watanabe H; Nair GB; Sack DA; Islam MA

Current Microbiology, Vol.52, No.2, 108-111, 2006

DOI10.1007/s00284-005-0140-9 Export Citation

Fluoroquinolone resistance linked to both gyrA and parC mutations in the quinolone resistance-determining region of Shigella dysenteriae type 1

Talukder KA, Khajanchi B, Islam M, Islam Z, Dutta DK, Rahman M, Watanabe H, Nair GB, Sack DA, Islam MA

We examined the quinolone resistance-determining region (QRDR) of gyrA, gyrB, and parC of recently isolated fluoroquinolone-resistant S. dysenteriae type 1 strains from south Asia and compared data with fluoroquinolone-susceptible strains associated with previous epidemics of 1978, 1984, and 1994. In fluoroquinolone-resistant strains, double mutations (Ser(83) -> Leu, Asp(87) -> Asn or Gly) and a single mutation (Ser(80) -> Ile) were detected in the QRDRs of gyrA and parC, respectively.