A liquid-junction-type interface where a thin spraying capillary is inserted inside the separation capillary was constructed for coupling nonaqueous wide-bore capillary, electrophoresis: (CE) to mass spectrometry (MS). The robust structure of the interface, provided fairly easy capillary handling. The study was carried out with uncoated CE capillaries of 200 and 320 mum inner diameter (ID). 1-Propanol-acetonitrile (80:20 v/v) with acetate electrolyte provided a low conducting medium for CE and good spraying conditions for electrospray ionization (ESI) without sheath-flow and drying gas. Methamphetamine, alprenolol, and levorphanol served as model compounds. Approximate detection limits with the 200 mum ID capillary were 35-265 ng/mL.