Human Immunodeficiency Virus type 1 (HIV-1) reverse transcriptase is an important target for chemotherapeutic agents against the AIDS disease. 4,5,6,7-Tetrahydro-5-methylimidazo[4,5,1-jk][1,4] benzodiazepin-2(1H)-ones(TIBO) derivatives are potent non-nucleoside reverse transcriptase inhibitors (NNRTIs). In the present work, quantitative structure-activity relationship (QSAR) analysis for a set of 82 TIBO derivatives has been investigated by means of a three-layered neural network (NN). It has been shown that NN can be a potential tool in the investigation of QSAR analysis compared with the models given in the literature. NN gave good statistical results both in fitting and prediction processes (0.861less than or equal tor(2)less than or equal to0.928, 0.839less than or equal toq(2)less than or equal to0.845). The relevant factors controlling the anti-HIV-1 activity of TIBO derivatives have been identified. The results are along the same lines as those of our previous studies on HEPT derivatives and indicate the importance of the hydrophobic parameter in modeling the QSAR for TIBO derivatives.