Chitosan의 화학적 Modification; 1.Chitosan-g-Poly(4-vinylpyridine)그라프트 공중합체의 합성 및 특성

김공수; 임정규; 조석형; 김수종

Polymer(Korea), Vol.17, No.2, 222-230, March, 1993

Chemical Modification of Chitosan; 1.Synthesis and Characterization of Chitosan-g-Poly(4-vinyl-pyridine) Graft Copolymers

김공수, 임정규, 조석형, 김수종

초록

Chitosan에 4-vinylpyridine의 그라프트 공중합은 수용액중에서 개시제로 ceric ammonium nitrate(CAN)를 사용하여 행하였으며 모너머의 농도가 0.2mol/l일 때 그라프트 공중합의 최적조건은 반응시간;2시간, 반응온도;30℃, 개시제농도;3.5×10^-3mol/l이었다. Glutaraldehyde로 가교시킨 공중합체의 팽윤도는 pH에 매우 의존적이며 특히 pH4∼pH6에서 급격히 변화하였다. 또한, 인장강도와 신장율은 그라프트율이 증가할수록 증가하였으나 그라프트율이 매우 높은 경우는 신장율이 다소 감소하였다.

Graft copolymerization of 4-vinylpyridine onto chitosan was investigated in an aqueous medium by using ceric ammonium nitrate(CAN) as initiator. The optimum conditions for the graft copolymerization were reaction time;2hrs., reaction temperature;30℃, initiator concentration;3.5×10^-3mol/l, when the monomer concentration was 0.2mol/l. The aqueous equilibrium swelling properties of a series of crosslinked copolymers using glutaraldehyde as crosslinker were measured as a function of pH at 25℃. The degree of swelling is highly pH dependent, and, especially, the variation of water content was very abrupt between pH4.6 and pH6.0. Tensile strength and elongation value of higher grafted copolymer decreased.

[References]

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Kataoka S, Kobunshi Ronbunshu, 39, 759 (1982)
Hattori S, Andrade JD, Hibbs JB, Gregonis DE, King RN, J. Colloid Interface Sci., 104, 72 (1985)
Kaifu K, Komai T, J. Biomed. Mater. Res., 16, 757 (1982)
Hos WM, Miyazari S, Takeda M, Chem. Pharm. Bull., 33, 3986 (1985)
Sawayanagi Y, Nambu N, Nagai T, Chem. Pharm. Bull., 31, 2507 (1983)
Stanley WL, Watters GC, Chan B, Mercer JM, Biotechnol. Bioeng., 17, 315 (1975)
Shigeno Y, Kondo K, Takemoto K, J. Macromol. Sci.-Chem., A17, 571 (1982)
Kojima K, Yoshikuni M, Suzuki T, J. Appl. Polym. Sci., 24, 1587 (1979)
Graczyk T, Hornof V, J. Polym. Sci. A: Polym. Chem., 26, 2019 (1988)
Kim YB, Jung BO, Kim KS, Kang YS, Kim KH, Polym.(Korea), 12(8), 678 (1988)
Kim YB, Jung BO, Kang YS, Kim KS, Kim JI, Kim KH, Polym.(Korea), 13(2), 126 (1989)
Cho SH, Kim KS, Kim KH, Shin JS, Polym.(Korea), 14(1), 9 (1990)
Kim KS, Cho SH, Chun YC, Shin JS, Kim KH, Lim JS, Polym.(Korea), 14(4), 385 (1990)
Sannan T, Kurita K, Iwakura Y, Macromol. Chem., 177, 3589 (1976)
Kurita K, Sannan T, Iwakura Y, J. Appl. Polym. Sci., 23, 511 (1979)
Lee VFP, Thesis Univ. Michigan Xerox Univ. Microfilms Ann. Arbor (1974)
McDowall DJ, Gupta BS, Stannett VT, Prog. Polym. Sci., 10, 1 (1984)
Schwab E, Stannett V, Rakowitz DH, Magrane JK, Tappi, 45, 390 (1962)
Hebeish A, Mehta PG, J. Appl. Polym. Sci., 12, 1625 (1968)
Ogiwara Y, Ogiwara Y, Kubota H, J. Polym. Sci. A: Polym. Chem., 5, 2791 (1967)
Suzuki K, Kido I, Takeuchi H, Nakazawa S, Yoshida T, Hata S, Sen-I Gakkaishi, 20, 311 (1964)
Rao SR, Kapur SL, J. Appl. Polym. Sci., 13, 2649 (1969)

[Referenced By]

[1] Eiden CA, Jewell CJ, Wightman JP, J. Appl. Polym. Sci., 25, 1587 (1980)

[2] Maruca R, Suder BJ, Wightman JP, J. Appl. Polym. Sci., 27, 4827 (1982)

[3] Pittalis F, Bartoli F, Giovanuoni G, Eur. Patent, Appl. 77, 98 (1981)

[4] Uragami T, Yoshida F, Sugihara M, Macromol. Chem. Rapid Commun., 4, 99 (1983)

[5] Kikuchi Y, Takebayashi T, Bull. Chem. Soc. Jpn., 55, 2307 (1982)

[6] Bough WA, Food Product Development, 11, 90 (1977)

[7] Kataoka S, Kobunshi Ronbunshu, 39, 759 (1982)

[8] Hattori S, Andrade JD, Hibbs JB, Gregonis DE, King RN, J. Colloid Interface Sci., 104, 72 (1985)

[9] Kaifu K, Komai T, J. Biomed. Mater. Res., 16, 757 (1982)

[10] Hos WM, Miyazari S, Takeda M, Chem. Pharm. Bull., 33, 3986 (1985)

[11] Sawayanagi Y, Nambu N, Nagai T, Chem. Pharm. Bull., 31, 2507 (1983)

[12] Stanley WL, Watters GC, Chan B, Mercer JM, Biotechnol. Bioeng., 17, 315 (1975)

[13] Shigeno Y, Kondo K, Takemoto K, J. Macromol. Sci.-Chem., A17, 571 (1982)

[14] Kojima K, Yoshikuni M, Suzuki T, J. Appl. Polym. Sci., 24, 1587 (1979)

[15] Graczyk T, Hornof V, J. Polym. Sci. A: Polym. Chem., 26, 2019 (1988)

[16] Kim YB, Jung BO, Kim KS, Kang YS, Kim KH, Polym.(Korea), 12(8), 678 (1988)

[17] Kim YB, Jung BO, Kang YS, Kim KS, Kim JI, Kim KH, Polym.(Korea), 13(2), 126 (1989)

[18] Cho SH, Kim KS, Kim KH, Shin JS, Polym.(Korea), 14(1), 9 (1990)

[19] Kim KS, Cho SH, Chun YC, Shin JS, Kim KH, Lim JS, Polym.(Korea), 14(4), 385 (1990)

[20] Sannan T, Kurita K, Iwakura Y, Macromol. Chem., 177, 3589 (1976)

[21] Kurita K, Sannan T, Iwakura Y, J. Appl. Polym. Sci., 23, 511 (1979)

[22] Lee VFP, Thesis Univ. Michigan Xerox Univ. Microfilms Ann. Arbor (1974)

[23] McDowall DJ, Gupta BS, Stannett VT, Prog. Polym. Sci., 10, 1 (1984)

[24] Schwab E, Stannett V, Rakowitz DH, Magrane JK, Tappi, 45, 390 (1962)

[25] Hebeish A, Mehta PG, J. Appl. Polym. Sci., 12, 1625 (1968)

[26] Ogiwara Y, Ogiwara Y, Kubota H, J. Polym. Sci. A: Polym. Chem., 5, 2791 (1967)

[27] Suzuki K, Kido I, Takeuchi H, Nakazawa S, Yoshida T, Hata S, Sen-I Gakkaishi, 20, 311 (1964)

[28] Rao SR, Kapur SL, J. Appl. Polym. Sci., 13, 2649 (1969)