The paper reports on the experimental results recorded in a liquid desiccant system for the air conditioning of an university building. The plant is composed by a desiccant column to treat the exhausted air fed by a solution H2O-LiBr, operating both in winter and in summer mode. In winter the system operates an effective heat recovery on the exhaust air; in summer the plant dehumidifies the ambient air to face the latent load. The measured performances during winter operation are presented to evaluate the behaviour of the system as a whole and of the various components. Copyright (c) 2006 John Wiley & Sons, Ltd.