The transdermal drug delivery (TDD) has got main advantage over the conventional oral delivery and maintaining the plasma drug level at a plateau over a long period of time. The phenomenon is taking place at the patch-skin interface, in particular the adhesion of a polymeric nanoscale pressure sensitive adhesive (PNPSA) film loaded with drug. The major requirements of this PNPSA are they should stick firmly to a difficult substrate (skin) and they should be easily and cleanly removed from the substrate when desired. The PNPSA nanocomposite P(EHA-co-AA)/SS is prepared by the emulsion copolymerization of two acrylic monomers, 2-ethyl hexylacrylate (EHA) and acrylic acid (AA) using a silicone additive like sodium silicate (SS). The TDD patch consists of a nanoscale silicone based polymeric adhesive i.e., P(EHA-co-AA)/SS and a drug Cloxacillin sodium an antibiotic. The prepared polymeric nanocomposites can carry drug and these bioactives are entrapped in the polymer matrix as particulates enmesh or bound to the particle surface by physical adsorption. The well characterized novel nanocomposites exhibited significant PSA performance in TDD system. In view of its medical application, the biodegradation study by activated sludge water indicated the nanocomposite to be environmentally friendly.