Journal of the American Chemical Society, Vol.129, No.42, 12682-12682, 2007
Rapid access to polyprenylated phloroglucinols via alkylative dearomatization-annulation: Total synthesis of (+/-)-clusianone
A concise approach to the bicyclo[3.3.1]nonane framework of the polyprenylated phloroglucinol natural products utilizing a tandem alkylative dearomatization-annulation sequence is described. Syntheses of (+/-)-clusianone and a complex adamantane framework have been achieved using the developed methodology.