A series of CeO2-ZrO2 mixed oxides were prepared using coprecipitation method and characterized by BET, oxygen storage capacity (OSC), Xray diffraction (XRD) and H-2-temperature-programmed reduction (H-2-TPR). The catalytic activities toward toluene combustion were investigated in a micro-reactor. The results demonstrate that the catalytic activity of Pt/gamma-Al2O3/Ce0.50Zr0.50O2 monolithic catalyst can be greatly improved by doping metal into Ce0.50Zr0.50O2. When doping Y and Mn into Ce0.50Zr0.50O2 simultaneously, the catalyst Pt/gamma-Al2O3/Ce0.40Zr0.40Y0.10Mn0.10Ox shows the highest activity. The T-10 (the temperature of 10% toluene conversion) and the complete conversion temperature (the temperature of 90% toluene conversion) of toluene are 443 and 489 K, respectively. Gas hourly space velocity (GHSV) results show that the prepared catalyst can be applied in a wide range of GHSV (from 12,000 to 20,000 h(-1)). The catalyst prepared shows great potential for practical application. (c) 2007 Elsevier B.V. All rights reserved.