자극감응성 고분자막의 제조와 약물투과특성 : Ⅱ. 화학개시제에 의한 폴리우레탄다공성막의 그라프트화와 리보플라빈의 투과특성

임성윤; 이영무; 김진홍; 조종수; 성용길

Polymer(Korea), Vol.18, No.3, 391-398, May, 1994

Preparation of Stimuli-Responsive Polymeric Membranes and Their Permeation Characteristics of Drugs :Ⅱ. Graft Polymerization of Porous Polyurethane Membranes by Chemical Initiation Method and Their Riboflavin Permeation

임성윤, 이영무, 김진홍, 조종수, 성용길

초록

폴리우레탄 다공성막을 상전이법으로 제조하고 막표면에 5가지 단량체들을 ceric ammonium nitrate(CAN)을 사용하여 크라프트반응시켰다. 사용한 단량체들은 아크릴아미드, 메타크릴아미드, 아크릴산, 메타크릴산 및 디에틸아미노에틸메타크릴레이트이다. 이들 그라프트막을 통해 리보플라빈의 투과거동을 살펴보았다. 아크릴아미드와 메타크릴아미드가 그라프트된 경우에는 pH에 대한 투과도변화가 나타나지 않은 반면 아크릴산, 메타크릴산, 디에틸아미노에틸메타크릴레이트가 그라프트된 경우에는 pH증가에 따라 투과도가 감소하였다.

Porous polyurethane(PU) membranes were prepared by phase inversion method. Surfaceof PU membrane was reacted with five monomers using ceric ammonium nitrate(CAN). Five monomers include acrylamide, methacrylamide, acrylic acid and N.N-diethylaminoethyl methacrylate. Permeation behavior of riboflavin was observed using these graft membranes. Poly(acrylamide-g-urethane) and poly(methacrylamide-g-urethane) membranes did not show the pH sensitivity for riboflavin permeation while poly(acrylic acid-g-urethane), poly(methacrylic acid-g-urethane) and poly(N,N-diethylaminoethyl methacrylate-g-urethane) membranes showed a decrease in permeability of riboflavin as pH increased.

[References]

Zattaroni A, Chemtech., 757 (1980)
Zattaroni A, Chemtech., 82 (1976)
Creque H, Langer R, Folkman J, Diabetes, 35, 684 (1986)
Langer R, Folkman J, Nature, 263, 797 (1976)
Okahata Y, Seki T, Macromolecules, 17, 1880 (1984)
Okahata Y, Noguchi H, Seki T, Macromolecules, 20, 15 (1987)
Kitano H, Akatsuka Y, Ise N, Macromolecules, 24, 42 (1991)
Siegel RA, Falamarzian M, Firestone BA, Moxley C, J. Control. Release, 8, 179 (1988)
Hoffman S, Dong L, J. Control. Release, 15, 141 (1991)
Klumb LA, Horbett TA, J. Control. Release, 18, 59 (1992)
Kim JH, Kim JY, Lee YM, Kim KY, J. Appl. Polym. Sci., 44, 1823 (1992)
Chung DJ, Ito Y, Imanishi Y, J. Control. Release, 18, 45 (1992)
Okahata Y, Lim HJ, Nakamura G, Hachiya S, J. Am. Chem. Soc., 105, 4855 (1983)
Ito Y, Kotera S, Ibana M, Kono K, Imanishi Y, Polymer, 31, 2157 (1990)
Iwata H, Matsuda T, J. Membr. Sci., 38, 185 (1988)
Iwata H, Oodate M, Uyama Y, Amemiya H, Ikada Y, J. Membr. Sci., 55, 119 (1991)
Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 255 (1990)
Okano T, Bae YH, Kim SW, Pharm. Res., 8, 624 (1991)
Kim JH, Lee YM, Jung CN, J. Korean Ind. Eng. Chem., 3(2), 296 (1992)
Wijmans JG, Baaij JPB, Smolders CA, J. Membr. Sci., 14, 263 (1983)
Reuvers AJ, vandenBerg JWA, Smolders CA, J. Membr. Sci., 34, 45 (1987)
Feng XD, Sun YH, Qiu KY, Macromolecules, 18, 2105 (1985)
Arnold RJ, J. Colloid Sci., 12, 549 (1957)

[Referenced By]

[1] Zattaroni A, Chemtech., 757 (1980)

[2] Zattaroni A, Chemtech., 82 (1976)

[3] Creque H, Langer R, Folkman J, Diabetes, 35, 684 (1986)

[4] Langer R, Folkman J, Nature, 263, 797 (1976)

[5] Okahata Y, Seki T, Macromolecules, 17, 1880 (1984)

[6] Okahata Y, Noguchi H, Seki T, Macromolecules, 20, 15 (1987)

[7] Kitano H, Akatsuka Y, Ise N, Macromolecules, 24, 42 (1991)

[8] Siegel RA, Falamarzian M, Firestone BA, Moxley C, J. Control. Release, 8, 179 (1988)

[9] Hoffman S, Dong L, J. Control. Release, 15, 141 (1991)

[10] Klumb LA, Horbett TA, J. Control. Release, 18, 59 (1992)

[11] Kim JH, Kim JY, Lee YM, Kim KY, J. Appl. Polym. Sci., 44, 1823 (1992)

[12] Chung DJ, Ito Y, Imanishi Y, J. Control. Release, 18, 45 (1992)

[13] Okahata Y, Lim HJ, Nakamura G, Hachiya S, J. Am. Chem. Soc., 105, 4855 (1983)

[14] Ito Y, Kotera S, Ibana M, Kono K, Imanishi Y, Polymer, 31, 2157 (1990)

[15] Iwata H, Matsuda T, J. Membr. Sci., 38, 185 (1988)

[16] Iwata H, Oodate M, Uyama Y, Amemiya H, Ikada Y, J. Membr. Sci., 55, 119 (1991)

[17] Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 255 (1990)

[18] Okano T, Bae YH, Kim SW, Pharm. Res., 8, 624 (1991)

[19] Kim JH, Lee YM, Jung CN, J. Korean Ind. Eng. Chem., 3(2), 296 (1992)

[20] Wijmans JG, Baaij JPB, Smolders CA, J. Membr. Sci., 14, 263 (1983)

[21] Reuvers AJ, vandenBerg JWA, Smolders CA, J. Membr. Sci., 34, 45 (1987)

[22] Feng XD, Sun YH, Qiu KY, Macromolecules, 18, 2105 (1985)

[23] Arnold RJ, J. Colloid Sci., 12, 549 (1957)