Inorganic Chemistry, Vol.46, No.14, 5450-5452, 2007
Hydrolytic cleavage of DNA by a ruthenium(II) polypyridyl complex
The complex [Ru(bpy)(2)(BPG)]Cl-2 containing hydrogen-bond donor (N-H atoms) and acceptor (O atoms) groups mediates hydrolytic cleavage of plasmid pBR322 DNA in an enzyme-like manner. The kinetic aspects of DNA cleavage under pseudo- and true-Michaelis-Menten conditions are detailed.