In this article, wedge chill casting is used to provide a variation of the cooling rate for the study of cooling rate-dependent as-cast microstructure and mechanical properties of Zr-based metallic glasses with and without yttrium doping. In-situ formed crystalline phases and crystallization sequence are realized in the context of the cooling rate. Macro-hardness is studied via the Brinell ball indentation and the contact morphology is discussed on the basis of microstructure analysis.