A number of fluorodiol-containing polyurethanes were synthesized from the fluorodiols 1H,1H,12H,12H-perfluoro-1,12-dodecanediol (PFDDOL) and 2,2,3,3,tetrafluoro-1,4-butartediol (TF) and characterized using Fourier transform infrared spectroscopy, gel permeation chromatography, and electron spectroscopy for chemical analysis (ESCA). The effect of the fluorine content on the physical and surface properties of the polymers and on their blood compatibility was investigated. A higher content of fluorine atoms exposed on the surface results in a lower surface energy, a lower relative index of platelet adhesion, and a lower fibrinogen/albumin adsorption ratio (F/A ratio). The polyurethane containing a 50% molar ratio of PFDDOL and TF as the chain extender exhibited the lowest surface energy and superior blood compatibility (RIPA value, 0.06; F/A ratio, 0.672). (c) 2007 Wiley Periodicals, Inc.