This article describes the synthesis and characterization of new amphiphilic polymer conetworks containing hydrophilic poly(2,3-dihydroxypropyl methacrylate) or poly(ethylene glycol) methacrylate (PEGMA) and hydrophobic polyisobutylene chains. This conetworks were prepared by a two-step polymer synthesis. In the first step, a cationic copolymer of isobutylene and 3-isopropenyl-alpha,alpha-dimethylbenzyl isocyanate (IDI) was prepared. The isocyanate groups of the IB-IDI random copolymer were subsequently transformed in situ to methacrylate (MA) groups in reaction with 2-hydroxyethyl methacrylate (HEMA). In the second step, the resulting MA-multifunctional PIB-based crosslinker, PIB(MA)(n), with an average functionality of approximately four per chain, was copolymerized with 2,3-dihydroxypropyl methacrylate or poly(ethylene glycol) methacrylate by radical mechanism in tetrahydrofuran giving rise to amphiphilic conetworks containing 11-60 mol % of DHPMA or 10-12 mol % of PEGMA. The synthesized conetworks were characterized with solid-state C-13-NMR spectroscopy and differential scanning calorimetry. The amphiphilic nature of the conetworks was proved by swelling in both water and n-heptane.