The single genomic locus, A beta H-J-J, encodes three functionally distinct proteins aspartyl beta-hydroxylase, junctin and junctate by alternative splicing. Among these three proteins, junctin and junctate could play important roles in the regulation of intracellular Ca2+ by regulating either Ca2+ release from intracellular Ca2+ stores or Ca2+ influx in various biological processes. Here we review recent findings concerning the expressional regulations and the proposed functions of junctin and junctate. (c) 2007 Elsevier Inc. All rights reserved.