The concentration of CO2 in the atmosphere has to be stabilized, requiring a reduction in current emission rates in existing plants. This will be done by reducing the environmental burden imposed in such areas as materials input and CO2 emission reduction and using cleaner production, resources, and energy recycling. Any opportunities for emission reduction and CO2 reuse largely depend on existing plant and energy systems. CO2 can be separated from the outlet stream (purge gas) and from flue gas by a membrane or absorption system (absorber and regenerator) or adsorption system and reused as a reactant in a reactor system. Therefore, product yield can be increased and CO2 emissions reduced, simultaneously. CO2 emissions can be reduced at the source. The authors of this paper studied CO2 reuse in a methanol process, in which electricity can be generated using an open gas turbine, followed by a separator. Simultaneous optimization of a process structure and its parameters using simplified nonlinear programming (NLP) ensures an additional annual profit, influenced by reusing the flow rate of CO2. The additional electricity cogeneration and additional flow rates of the raw material could generate an additional profit of 2.79 MEUR/a.