Biochemical and Biophysical Research Communications, Vol.366, No.1, 23-28, 2008
Association of mitochondrial nitric oxide synthase activity with respiratory chain complex I
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions. (C) 2007 Elsevier Inc. All rights reserved.
Keywords:mitochondrial nitric oxide synthase;nitric oxide;respiratory chain complex I;mitochondrial respiration