Journal of the American Chemical Society, Vol.129, No.25, 7768-7768, 2007
Palladium-catalyzed direct functionalization of imidazolinone: Synthesis of dibromophakellstatin
The direct C-H functionalization of imidazolinone is achieved with Pd(OAc)(2)/NaOAc in DMSO. Dibromophakellstatin can be synthesized in five steps with 40% overall yield using this new C-H activation method.