The models of particle fouling and membrane blocking in a submerged membrane filtration are developed in this study. The effects of operating conditions, such as aeration intensity (air flow rate) and filtration pressure, on the filtration flux, membrane blocking, and cake formation are discussed thoroughly. The experimental results show that the filtration resistances due to cake formation and membrane blocking play significant roles in determining the overall filtration resistance, but the latter one is more dominant. An increase in aeration intensity leads the filtration flux to increase due to the reduction of cake formation on the membrane surface. However, a higher filtration pressure causes more severe membrane internal blocking and then to lower filtration flux. The cake properties and the filtration resistance due to membrane blocking are analyzed and can be regressed to empirical functions of filtration pressure. A force balance model for particle deposition on the membrane surface is also derived. In order to estimate the shear stress acting on the membrane surface, the diameter, shape, and rising velocity of air bubbles are analyzed based on hydrodynamics. Once the model coefficients are obtained, the pseudo-steady filtration flux under various conditions can be estimated by the proposed model and the basic filtration equation. The calculated results agree fairly well with the available experimental data.