This paper reports on upscaling of a new technology combining solar photo-Fenton and aerobic biological processes to successfully treat a saline industrial wastewater containing around 600 mg L-1 of a non-biodegradable compound (alpha-methylphenylglycine, MPG) and dissolved organic carbon (DOC) of between 400 and 600 mg L-1. Pilot-plant tests were used in designing this demonstration hybrid solar photocatalytic-biological plant with a 4 m(3) daily treatment capacity. It consists of a solar photo-Fenton reactor with 100 m(2) of solar compound parabolic collectors (CPCs) and an aerobic biological treatment plant based on an immobilized-biomass activated-sludge reactor (1 m(3)). The catalyst concentration was Fe2+ = 20 mg L-1. The overall efficiency in the combined system was around 95% mineralization. 50% of the initial DOC was degraded in the photo-Fenton pretreatment, and 45% was removed in the aerobic biological treatment.