화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.25, No.2, 308-322, March, 2008
DOI10.1007/s11814-008-0054-x  Export Citation
Differential expression of liver proteins in streptozotocin-induced diabetic rats in response to hypoglycemic mushroom polysaccharides
Hye Jin Hwang, Sang Woo Kim, Yu Mi Baek, Sung Hak Lee, Hee Sun Hwang, Suresh G. Kumar, Md. Atiar Rahman, and Jong Won Yun†
  • Department of Biotechnology, Daegu University, Gyungsan, Gyungbuk 712-714, Korea
E-mail:
We investigated the influence of hypoglycemic fungal extracellular polysaccharides (EPS) on the differential expression of liver proteins in streptozotocin (STZ)-induced diabetic rats. The results of diabetic study revealed that orally administrated EPS exhibited an excellent hypoglycemic effect, lowering the average plasma glucose level in EPS-fed rats to 55.1% with enhanced glucose tolerance. In the next step, we analyzed the differential expression patterns of rat liver proteins from each group to discover potent candidates for diabetes-associated proteins. 34 proteins were upregulated and 35 proteins were downregulated upon diabetes induction. Surprisingly, the altered levels of most proteins in the diabetic group were fully or partially restored to those of the non-diabetic control group by EPS treatment. Although the molecular basis of protein modulation after EPS administration in diabetic rats was not verified, the results of the proteomic analysis provide impetus for further studies to identify reliable biomarkers for diabetic therapy.
Keywords:Diabetic Rat;Liver Proteome;Phellinus baumii;Polysaccharides;Streptozotocin
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