화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.16, No.3, 189-193, April, 2008
Export Citation
Swelling Behavior and Drug Release of Poly(vinyl alcohol) Hydrogel Cross-Linked with Poly(acrylic acid)
Hongsik Byun, Byungpyo Hong, Sang Yong Nam1, Sun Young Jung2, Ji Won Rhim2, †, Sang Bong Lee3, and Go Young Moon4
  • Department of Chemical System Engineering, Keimyung University, Daegu 704-701, Korea
  • 1Department of Polymer Science and Engineering, Engineering Research Institute, i-Cube Center, Gyeongsang National University, Jinju 660-701, Korea
  • 2Department of Chemical Engineering and Nano-Bio Technology, Hannam University, Daejeon 305-811, Korea
  • 3Clean System Team, Korea Institute of Industrial Technology, Chungcheongnam-do 330-825, Korea
  • 4CRD, Research Park, LG Chem., Daejeon 305-380, Korea
E-mail:
Thermal cross-linking method of poly(vinyl alcohol) (PVA) using poly(acrylic acid) (PAA) was carried out on PVA/PAA hydrogels. The level of gelation was measured in the PVA/ PAA hydrogels with various PAA contents. The swelling behavior at various pHs showed that the swelling kinetics and water contents of the PVA/PAA hydrogels reached equilibrium after 30 h, and the time to reach the equilibrium state decreased with increasing PAA content in the hydrogel. The water content increased with increasing pH of the buffer solution. The permeation and release of the drug were tested using indomethacin as a model drug. The permeated and released amounts of the drug increased with decreasing the PAA content because of the low free volume in the hydrogel due to the higher cross-linking density. The kinetic profile of drug release at various pHs showed that all samples reached the equilibrium state within the 5 h.
Keywords:poly(vinyl alcohol);poly(acrylic acid);thermal cross-linking;hydrogel;swelling;drug release
  1. Ju HK, Kim SY, Lee YM, Polymer, 42(16), 6851 (2001)
  2. Peppas NA, Bures P, Leobandung W, Ichikawa W, Eur. J. Pharm. Biopharm., 50, 27 (2000)
  3. Hirasa O, Ito S, Yamauchi A, Fujishige S, Ichijo H, Polymer gels, fundamentals and biomedical application, Plenum Press, New York, 1991, pp.247
  4. Ju HK, Kim SY, Kim SJ, Lee YM, J. Appl. Polym. Sci., 83(5), 1128 (2002)
  5. Gudeman LF, Peppas NA, J. Membr. Sci., 107(3), 239 (1995)
  6. Kim SY, Lee YM, J. Appl. Polym. Sci., 74(7), 1752 (1999)
  7. Lee YM, Kim SH, Cho CS, J. Appl. Polym. Sci., 62(2), 301 (1996)
  8. Peppas NA, Wright SL, Eur J. Pharm. Biopharm., 46, 15 (1998)
  9. Byun JG, Lee YM, Cho CS, J. Appl. Polym. Sci., 61(4), 697 (1996)
  10. Shin HS, Kim SY, Lee YM, J. Appl. Polym. Sci., 65(4), 685 (1997)
  11. Shaheen SM, Yamaura K, J. Control. Release, 81, 367 (2002)
  12. Morimoto K, Nagayasu A, Fukanoki S, Morisaka K, Hyun SH, Ikada Y, Pharmaceut. Res., 6, 338 (1989)
  13. Nam SY, Lee YM, J. Membr. Sci., 135(2), 161 (1997)
  14. Kim SY, Cho SM, Lee YM, Kim SJ, J. Appl. Polym. Sci., 78(7), 1381 (2000)
  15. AMENDE MT, HARIHARAN D, PEPPAS NA, React. Polym., 25(2), 127 (1995)