화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.16, No.5, 473-480, July, 2008
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Biological Affinity and Biodegradability of Poly(propylene carbonate) Prepared from Copolymerization of Carbon Dioxide with Propylene Oxide
Gahee Kim, Moonhor Ree†, Heesoo Kim1, †, Ik Jung Kim1, Jung Ran Kim2, and Jong Im Lee2
  • Department of Chemistry, National Research Lab for Polymer Synthesis & Physics, Center for Integrated Molecular Systems,Polymer Research Institute, and BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, Korea
  • 1Department of Microbiology and Dongguk Medial Institute, Dongguk University College of Medicine, Gyeongju 780-714, Korea
  • 2Department of Pathology and Dongguk Medial Institute, Dongguk University College of Medicine, Gyeongju 780-714, Korea
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In this study we investigated bacterial and cell adhesion to poly(propylene carbonate) (PPC) films, that had been synthesized by the copolymerization of carbon dioxide (a global warming chemical) with propylene oxide. We also assessed the biocompatibility and biodegradability of the films in vivo, and their oxidative degradation in vitro. The bacteria adhered to the smooth, hydrophobic PPC surface after 4 h incubation. Pseudomonas aeruginosa and Enterococcus faecalis had the highest levels of adhesion, Escherichia coli and Staphylococcus aureus had the lowest levels, and Staphylococcus epidermidis was intermediate. In contrast, there was no adhesion of human cells (cell line HEp-2) to the PPC films, due to the hydrophobicity and dimensional instability of the surface. On the other hand, the PPC films exhibited good biocompatibility in the mouse subcutaneous environment. Moreover, contrary to expectation the PPC films degraded in the mouse subcutaneous environment. This is the first experimental confirmation that PPC can undergo surface erosion biodegradation in vivo. The observed biodegradability of PPC may have resulted from enzymatic hydrolysis and oxidative degradation processes. In contrast, the PPC films showed resistance to oxidative degradation in vitro. Overall, PPC revealed high affinity to bioorganisms and also good biodegradability.
Keywords:poly(propylene carbonate);bacterial adhesion;cell adhesion;biocompatibility;biodegradability
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