Properties of Blood Compatible Crosslinked Blends of Pellethene®/Multiblock Polyurethanes Containing Phospholipid Moiety/C-18 Alkyl Chain

Hye-Jin Yoo; Han-Do Kim

Macromolecular Research, Vol.16, No.7, 596-603, October, 2008

Hye-Jin Yoo, and Han-Do Kim^†

Department of Organic Material Science and Engineering, College of Engineering, Pusan National University, Busan 609-735, Korea

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To improve the mechanical properties, dimensional stability and blood compatibility, the biomedical material Pellethene® was blended with multiblock polyurethane (MPU) containing phospopholipid /long alkyl chain (C-18) at the various MPU contents and crosslinked using dicumyl peroxide as a crosslinking agent. The maximum MPU content for stable Pellethene®/MPU blended films was approximately 30 wt%. The optimum crosslinking agent content and crosslinking time with respect to the mechanical properties were 4 wt% and 3 h, respectively. The mechanical properties (tensile strength and elongation at break) and water absorption of the crosslinked blend film increased with increasing MPU content. The test of platelet adhesion on the surfaces of the crosslinked blend film showed a decrease in the level of platelet adhesion from 70% to 6% with increasing MPU content from 0 to 30 wt%. These results suggest that the crosslinked Pellethene®/MPU-30 (MPU content: 30 wt%) sample has strong potential as a novel material for blood compatible material applications.

Keywords:polyurethane;phospholipids;biomaterials;platelet adhesion

[References]

Lee JH, Ju YM, Kim DM, Biomaterials, 21, 683 (2000)
Korematsu A, Takemoti Y, Nakaya T, Inoue H, Biomaterials, 23, 263 (2002)
Park KD, Kim YS, Han DK, Kim YH, Lee EH, Suh H, Choi KS,, Biomaterials, 22, 851 (1998)
Cooper SL, Biomater J . Sci.-Polym. E, 10, 679 (1999)
Lelah MD and Cooper SL, Polyurethane in Medicine, FL, CRC Press, 1986, pp 57-110
Li YJ, Nakaya T, Zhang Z, J. Biomater. Appl., 12, 167 (1997)
Abraham GA, Roman JS, Biomaterials, 23, 1625 (2002)
Han DK, Park KD, Kim YH, J. Biomater. Sci. -Polym. E, 9, 163 (1998)
Uyama Y, Kato K, Ikada Y, Adv. Polym. Sci., 137, 3 (1998)
Marconi W, Galloppa A, Mattinell A, Piozzi A, Biomaterials, 16, 449 (1995)
Durrani AA, Hayward JA, Chapman A, Biomaterials, 7, 121 (1986)
Li YJ, Mattews K, Kodama HM, Nakaaya T, Macromol. Chem. Phys., 196, 143 (1995)
Korematsu A, Li YH, Murakami T, Nakaya T, J. Mater. Res., 14, 378 (1999)
Yung LL, Cooper SL, Biomaterials, 19, 31 (1998)
Grasel TG, Pierce JA, Cooper SL, J. Biomed. Mater. Res., 21, 815 (1987)
Munro MS, Eberhart RC, Naki NJ, Brink BE, Fry WJ, Amer. Soc. Artif. Int. Organs J., 6, 65 (1983)
Frautschi JR, Munro MS, Lloyd DR, Eberhart RC, Trans. Amer. Soc. Artif. Int. Organs., 29, 242 (1983)
Edmundson RS, Chem. Ind. (London), 20, 828 (1962)
Bailey FE and Koleske JY, Poly(ethylene oxide), Academic Press, New York, 1976, p 20
Lee JH, Kim SH, Polymer, 21, 332 (1997)
Boats JGF, Van der Does L, Bantjes A, Biomaterials, 7, 393 (1986)
Boats JGF, Van der Does L, Bantjes A, Brit. Polym. J., 19, 527 (1987)
Brinkman E, Poot A, Beugeling T, Van der Does L, Bantjes A, Int. J. Artif. organs, 12, 390 (1989)

[Referenced By]

[1] Lee JH, Ju YM, Kim DM, Biomaterials, 21, 683 (2000)

[2] Korematsu A, Takemoti Y, Nakaya T, Inoue H, Biomaterials, 23, 263 (2002)

[3] Park KD, Kim YS, Han DK, Kim YH, Lee EH, Suh H, Choi KS,, Biomaterials, 22, 851 (1998)

[4] Cooper SL, Biomater J . Sci.-Polym. E, 10, 679 (1999)

[5] Lelah MD and Cooper SL, Polyurethane in Medicine, FL, CRC Press, 1986, pp 57-110

[6] Li YJ, Nakaya T, Zhang Z, J. Biomater. Appl., 12, 167 (1997)

[7] Abraham GA, Roman JS, Biomaterials, 23, 1625 (2002)

[8] Han DK, Park KD, Kim YH, J. Biomater. Sci. -Polym. E, 9, 163 (1998)

[9] Uyama Y, Kato K, Ikada Y, Adv. Polym. Sci., 137, 3 (1998)

[10] Marconi W, Galloppa A, Mattinell A, Piozzi A, Biomaterials, 16, 449 (1995)

[11] Durrani AA, Hayward JA, Chapman A, Biomaterials, 7, 121 (1986)

[12] Li YJ, Mattews K, Kodama HM, Nakaaya T, Macromol. Chem. Phys., 196, 143 (1995)

[13] Korematsu A, Li YH, Murakami T, Nakaya T, J. Mater. Res., 14, 378 (1999)

[14] Yung LL, Cooper SL, Biomaterials, 19, 31 (1998)

[15] Grasel TG, Pierce JA, Cooper SL, J. Biomed. Mater. Res., 21, 815 (1987)

[16] Munro MS, Eberhart RC, Naki NJ, Brink BE, Fry WJ, Amer. Soc. Artif. Int. Organs J., 6, 65 (1983)

[17] Frautschi JR, Munro MS, Lloyd DR, Eberhart RC, Trans. Amer. Soc. Artif. Int. Organs., 29, 242 (1983)

[18] Edmundson RS, Chem. Ind. (London), 20, 828 (1962)

[19] Bailey FE and Koleske JY, Poly(ethylene oxide), Academic Press, New York, 1976, p 20

[20] Lee JH, Kim SH, Polymer, 21, 332 (1997)

[21] Boats JGF, Van der Does L, Bantjes A, Biomaterials, 7, 393 (1986)

[22] Boats JGF, Van der Does L, Bantjes A, Brit. Polym. J., 19, 527 (1987)

[23] Brinkman E, Poot A, Beugeling T, Van der Does L, Bantjes A, Int. J. Artif. organs, 12, 390 (1989)