Synthesis and Microphase Separation of Biodegradable Poly(ε-caprolactone)- Poly(ethylene glycol)-Poly(ε-caprolactone) Multiblock Copolymer Films

Jae Ho You; Sung-Wook Choi; Jung-Hyun Kim; Young Tae Kwak

Macromolecular Research, Vol.16, No.7, 609-613, October, 2008

Jae Ho You, Sung-Wook Choi, Jung-Hyun Kim^†, and Young Tae Kwak¹

Nanosphere Process and Technology Laboratory, Department of Chemical Engineering, Yonsei University, Seoul 120-749, Korea
¹Department of Thoracic and Cardiovascular Surgery, East-West Neo Medical Center, College of Medicine, Kyung Hee University, Seoul 130-701, Korea

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Poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) multiblock copolymers at various hydrophobic-hydrophilic ratios were successfully synthesized by the chain extension of triblock copolymers through isocyanate (hexamethylene diisocyanate). Biodegradable films were prepared from the resulting multiblock copolymers using the casting method. The mechanical properties of the films were improved by chain extension of the triblock copolymers, whereas the films prepared by the triblock copolymers were weak and brittle. Atomic force microscopy (AFM) of the multiblock copolymer film showed that the hydrophilic PEG had segregated on the film surface. This is consistent with the observed contact angle of the films.

Keywords:poly(ε-caprolactone) (PCL);poly(ethylene glycol) (PEG);multiblock copolymers;film properties;microphase separation

[References]

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Barakat I, Dubois PH, Grandfils CH, Jerome R, J.Polym. Sci. Part A: Polym. Chem., 39, 294 (2002)
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Kricheldorf HR, Rost S, Polymer, 46(10), 3248 (2005)
Cohn D, Hotovely-Salomon A, Polymer, 46(7), 2068 (2005)
Chen XH, Mccarthy SP, Gross RA, Macromolecules, 30(15), 4295 (1997)
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[Referenced By]

[Related Articles]

[1] Albertsson AC, Edlund U, Adv. Drug Deliver. Rev., 55, 585 (2003)

[2] Middleton JC, Tipton AJ, Biomaterials, 21, 2335 (2000)

[3] Woei K, Hutmacher DW, Schantz JT, Seng C, Too HP, Chye T, Phan TT, Teoh SH, Tissue Eng., 7, 441 (2001)

[4] Le Ray AM, Chiffoleau S, Iooss P, Grimandi G, Gouyette A, Daculsi G, Merle C, Biomaterials, 24, 443 (2003)

[5] Pitt CG, Jeffcoat AR, Zweidinger RA, Schindler A, J. Biomed. Mater. Res., 13, 497 (1979)

[6] Hong SW, Kim KH, Huh J, Ahn CH, Jo WH, Macromol. Res., 13(5), 397 (2005)

[7] Yoo JS, Kim MS, Lee DS, Kim BS, Kim JH, Macromol. Res., 14(1), 117 (2006)

[8] Im SJ, Choi YM, Subramanyam E, Huh KM, Park K, Macromol. Res., 15(4), 363 (2007)

[9] Lin W, J. Biomed. Mater. Res., 47, 420 (1999)

[10] Ye WP, Du FS, Jin JY, Yang JY, Xu Y, React. Funct. Polym., 32(2), 161 (1997)

[11] Yavuz H, Babac C, Polym. Degrad. Stabil., 75, 431 (2002)

[12] Barakat I, Dubois PH, Grandfils CH, Jerome R, J.Polym. Sci. Part A: Polym. Chem., 39, 294 (2002)

[13] Bero M, Czapla B, Dobrzy´n ski P, Janeczek H, Kasperczyk J, Macromol. Chem. Phys., 200, 911 (1999)

[14] Ge HX, Hu Y, Jiang XQ, Cheng DM, Yuan YY, Bi H, Yang CZ, J. Pharm. Sci., 91, 1463 (2002)

[15] He F, Li SM, Vert M, Zhuo RX, Polymer, 44(18), 5145 (2003)

[16] Harris JM, Topics in applied chemistry, Harris JM, Ed., New York, Plenum Press, 1992, pp 1-14.

[17] Sbarbati del Guerra R, Cristallini C, Rizzi N, Barsacchi R, Guerra GD, Tricoli M, Cerrai P, J. Mater. Sci.; Mater.Med., 5, 891 (1994)

[18] Bogdanov B, Vidts A, Schacht E, Berghmans H, Macromolecules, 32(3), 726 (1999)

[19] Li SM, Chen XM, Gross RA, McCarthey SP, J. Mater. Sci.; Mater. Med.,, 11, 227 (2000)

[20] Kumar MN, Kumar N, Domb AJ, Arora M, Adv.Polym. Sci., 160, 45 (2002)

[21] Kreuter J, Colloidal drug delivery systems, New York, Marcel Dekker, 1994, pp 219-342

[22] Otsuka H, Nagasaki Y, Kataoka K, Adv. Drug Deliver.Rev., 55, 403 (2003)

[23] Kricheldorf HR, Rost S, Polymer, 46(10), 3248 (2005)

[24] Cohn D, Hotovely-Salomon A, Polymer, 46(7), 2068 (2005)

[25] Chen XH, Mccarthy SP, Gross RA, Macromolecules, 30(15), 4295 (1997)

[26] Gilding DK, Reed AM, Polymer, 20, 1454 (1979)

[27] Cheng Z, Teoh SH, Biomaterials, 25, 1991 (2004)

[28] Al-Nasassrah MA, Podczeck F, Newton JM, Eur. J.Pharm. Biopharm., 46, 31 (1998)