Computational simulation has been performed to design optimally the filtration system for IGCC pilot plant. It was analyzed how the different inflow pattern influences the flow field and the particle behavior in a filter vessel. The particle loading onto the filter surface lowers significantly and decreases dramatically with particle size when the dusty gas flows into the filter vessel with a shroud tube through a tangential inlet setup tangentially on the vessel outer wall. However, the particle loading is considerably high when the dusty gas enters the filter vessel through a normal inlet setup vertically on the vessel top wall, and the decrease of the particle loading with particle size is not steeper compared with the tangential inflow pattern.