Antimicrobial activities against methicillin-resistant Staphylococcus aureus from macroalgae

In Hae Kim; Jae-Hwa Lee

Journal of Industrial and Engineering Chemistry, Vol.14, No.5, 568-572, September, 2008

DOI10.1016/j.jiec.2008.04.004 Export Citation

Antimicrobial activities against methicillin-resistant Staphylococcus aureus from macroalgae

In Hae Kim¹, and Jae-Hwa Lee^{2, 1, †}

¹Department of Pharmaceutical Engineering, College of Medical Life Science, Silla University, Kwaebop-dong 1-1, Busan 617-736, Republic of Korea
²Department of Bioscience and Biotechnology, College of Engineering, Silla University, Kwaebop-dong 1-1, Busan 617-736, Republic of Korea

E-mail:

The aim of our studies was to identify seaweeds that possess activities against gram-positive and gram-negative bacteria, methicillin-resistant Staphylococcus aureus (MRSA) strains and bacteria pathogenic in fish. Methanol extracts of 33 species of seaweeds (21 phaeophyta, 8 rhodophyta, 3 chlorophyta and 1 phanergamae) were screened for their antimicrobial activities against bacteria pathogenic in fish (Vibrio parahemolyticus and Edward tarda) and against three MRSA strains. The seaweed extracts of Esiena bicyclis (B32) and Sargassum sp. (B36) showed strong antibacterial activities against MRSA strains, Vibrio parahemolyticus and Edward tarda. However, none of the seaweed extracts showed antifungal activity against Candida albicans nor did they have any hemolytic activity against human erythrocytes.

Keywords:Methicillin-resistant Staphylococcus aureus (MRSA);Phaeophyta;Rhodophyta;Chlorophyta;Phanergamae;Esiena bicyclis

[References]

Walsh FM, Amyes SG, Curr. Opin. Microbiol., 7, 439 (2004)
Lyon BR, Skurray R, Microbiol. Rev., 51, 89 (1987)
Petinaki E, Miriagou V, Tzouvelekis LS, Pournaras S, Hatzi F, Kontos F, Maniati M, Maniatis AN, Bacterial Resistance Study Group of Thessaly, Int. J. Antimicrob. Agents 18 (2001) 61
Wang JT, Chen YC, Yang TL, Chang SC, Diagn. Microbiol. Infect. Dis., 42, 199 (2002)
Dinges M, Orwin PM, Schlievert PM, Microbiol. Rev., 13, 16 (2000)
Hwang JM, Yeom SH, Jung KY, J. Ind. Eng. Chem., 13(3), 474 (2007)
Isnansetyo A, Cui L, Hiramatsu K, Kamei Y, Int. J. Antimicrob. Agents, 22, 545 (2003)
Lee HW, Yoon JH, Sohn JH, Lee KH, Yeh BI, Park DW, Kim HW, Choi JW, J. Microbiol. Biotechnol., 13, 354 (2003)
Witte W, J. Antimicrob. Chemother., 44, 1 (1999)
Barber M, J. Clin. Pathol., 14, 385 (1961)
Jevons MP, Br. Med. J., 14, 124 (1961)
Chambers HF, Clin. Microbiol. Rev., 1, 173 (1988)
Mulligan ME, Murray-Leisure KA, Ribner BS, Standiford HC, John JF, Korvick JA, Kauffman CA, V.L. Yu, Am. J. Med., 94, 313 (1993)
Al-Masudi SB, Day MJ, Russell AD, J. Appl. Bacteriol., 70, 279 (1991)
Kim KS, Seo HA, Oh CY, Kim H, Kim JB, J. Microbiol. Biotechnol., 11, 788 (2001)
Jung HJ, Choi KS, Lee DG, J. Microbiol. Biotechnol., 15, 1039 (2005)
Lee SW, Kim CJ, J. Microbiol. Biotechnol., 9, 572 (1999)
Bansemir A, Blume M, Schroder S, Lindequist U, Aquaculture, 252, 79 (2006)
Mayer AM, Hamann MT, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 132, 315 (2002)
Kim IH, Lee DG, Lee SH, Ha JM, Ha BJ, Kim SK, Lee JH, Biotechnol. Bioprocess Eng., 12, 579 (2007)
Newman DJ, Cragg GM, Snader KM, J. Nat. Prod., 66, 1022 (2003)
Seo YW, Kang SH, Lee HJ, Kim YA, Youn HJ, Lee BJ, Chung HS, Biotechnol. Bioprocess Eng., 11, 160 (2006)
Gonzalez del Val A, Platas G, Basilico A, Cabello A, Gorrochategui J, Suay I, Vicente F, Portillo E, Jimenez del Rio M, Reina GG, Pelaez F, Int. Microbiol., 4, 53 (2001)
Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, Fencial W, Proc. Natl. Acad. Sci. U.S.A., 100, 6916 (2003)
Mahasneh I, Jamal M, Kashashneh M, Zibdeh M, Microbiology, 83, 23 (1995)
Hultmart D, Engstrom A, Bennich H, Kapur R, Boman HG, Eur. J. Bichem., 127, 207 (1982)
Seo JK, Crawford JM, Stone KL, Noga EJ, Biochem. Biophys. Res. Commun., 338(4), 1998 (2005)
Kim JS, J. Ind. Eng. Chem., 13(5), 718 (2007)
Kim CH, Choi KS, J. Ind. Eng. Chem., 8(1), 71 (2002)
Venditti M, Santini C, Serra P, Micozzi A, Gentile G, Maritina P, Antimicrob. Agents Chemother., 33, 209 (1989)
Zasloff M, Martin B, Chen HC, Proc. Natl. Acad. Sci. U.S.A., 85, 910 (1988)
Feder R, Dagan A, Mor A, J. Biol. Chem., 275, 4230 (2000)

[Related Articles]

[1] Walsh FM, Amyes SG, Curr. Opin. Microbiol., 7, 439 (2004)

[2] Lyon BR, Skurray R, Microbiol. Rev., 51, 89 (1987)

[3] Petinaki E, Miriagou V, Tzouvelekis LS, Pournaras S, Hatzi F, Kontos F, Maniati M, Maniatis AN, Bacterial Resistance Study Group of Thessaly, Int. J. Antimicrob. Agents 18 (2001) 61

[4] Wang JT, Chen YC, Yang TL, Chang SC, Diagn. Microbiol. Infect. Dis., 42, 199 (2002)

[5] Dinges M, Orwin PM, Schlievert PM, Microbiol. Rev., 13, 16 (2000)

[6] Hwang JM, Yeom SH, Jung KY, J. Ind. Eng. Chem., 13(3), 474 (2007)

[7] Isnansetyo A, Cui L, Hiramatsu K, Kamei Y, Int. J. Antimicrob. Agents, 22, 545 (2003)

[8] Lee HW, Yoon JH, Sohn JH, Lee KH, Yeh BI, Park DW, Kim HW, Choi JW, J. Microbiol. Biotechnol., 13, 354 (2003)

[9] Witte W, J. Antimicrob. Chemother., 44, 1 (1999)

[10] Barber M, J. Clin. Pathol., 14, 385 (1961)

[11] Jevons MP, Br. Med. J., 14, 124 (1961)

[12] Chambers HF, Clin. Microbiol. Rev., 1, 173 (1988)

[13] Mulligan ME, Murray-Leisure KA, Ribner BS, Standiford HC, John JF, Korvick JA, Kauffman CA, V.L. Yu, Am. J. Med., 94, 313 (1993)

[14] Al-Masudi SB, Day MJ, Russell AD, J. Appl. Bacteriol., 70, 279 (1991)

[15] Kim KS, Seo HA, Oh CY, Kim H, Kim JB, J. Microbiol. Biotechnol., 11, 788 (2001)

[16] Jung HJ, Choi KS, Lee DG, J. Microbiol. Biotechnol., 15, 1039 (2005)

[17] Lee SW, Kim CJ, J. Microbiol. Biotechnol., 9, 572 (1999)

[18] Bansemir A, Blume M, Schroder S, Lindequist U, Aquaculture, 252, 79 (2006)

[19] Mayer AM, Hamann MT, Comp. Biochem. Physiol. C Toxicol. Pharmacol., 132, 315 (2002)

[20] Kim IH, Lee DG, Lee SH, Ha JM, Ha BJ, Kim SK, Lee JH, Biotechnol. Bioprocess Eng., 12, 579 (2007)

[21] Newman DJ, Cragg GM, Snader KM, J. Nat. Prod., 66, 1022 (2003)

[22] Seo YW, Kang SH, Lee HJ, Kim YA, Youn HJ, Lee BJ, Chung HS, Biotechnol. Bioprocess Eng., 11, 160 (2006)

[23] Gonzalez del Val A, Platas G, Basilico A, Cabello A, Gorrochategui J, Suay I, Vicente F, Portillo E, Jimenez del Rio M, Reina GG, Pelaez F, Int. Microbiol., 4, 53 (2001)

[24] Kubanek J, Jensen PR, Keifer PA, Sullards MC, Collins DO, Fencial W, Proc. Natl. Acad. Sci. U.S.A., 100, 6916 (2003)

[25] Mahasneh I, Jamal M, Kashashneh M, Zibdeh M, Microbiology, 83, 23 (1995)

[26] Hultmart D, Engstrom A, Bennich H, Kapur R, Boman HG, Eur. J. Bichem., 127, 207 (1982)

[27] Seo JK, Crawford JM, Stone KL, Noga EJ, Biochem. Biophys. Res. Commun., 338(4), 1998 (2005)

[28] Kim JS, J. Ind. Eng. Chem., 13(5), 718 (2007)

[29] Kim CH, Choi KS, J. Ind. Eng. Chem., 8(1), 71 (2002)

[30] Venditti M, Santini C, Serra P, Micozzi A, Gentile G, Maritina P, Antimicrob. Agents Chemother., 33, 209 (1989)

[31] Zasloff M, Martin B, Chen HC, Proc. Natl. Acad. Sci. U.S.A., 85, 910 (1988)

[32] Feder R, Dagan A, Mor A, J. Biol. Chem., 275, 4230 (2000)