Multiparticulation of ciprofloxacin HCl-encapsulated chitosan microspheres using poly(DL-lactide-co-glycolide)

Young-Il Jeong; Don-Gon Kim; Dong-Hyuk Seo; Mi-Kyeong Jang; Jae-Woon Nah

Journal of Industrial and Engineering Chemistry, Vol.14, No.6, 747-751, November, 2008

DOI10.1016/j.jiec.2008.05.004 Export Citation

Multiparticulation of ciprofloxacin HCl-encapsulated chitosan microspheres using poly(DL-lactide-co-glycolide)

Young-Il Jeong, Don-Gon Kim, Dong-Hyuk Seo, Mi-Kyeong Jang , and Jae-Woon Nah^†

Department of Polymer Science and Engineering, Sunchon National University, Jeonnam 540-742, Republic of Korea

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In this study, we prepared poly(DL-lactide-co-glycolide) (PLGA)-coated chitosan oligosaccharide (COS) microspheres. Ciprofloxacin HCl (CIP)-encapsulated COS microspheres were prepared by the pressure homogenization and spray drying technique. The microspheres have spherical shapes and their particle size was in the range of 2-3 μm in diameter. When they were coated with PLGA, PLGA-coated COS microspheres showed rough spherical surfaces, indicating that COS microspheres might be existed on the surface of particles in addition to the inside of particles. The efficiency of loading and size of particle were increased with the increase of the amount of PLGA feeding amount. At the effect of PLGA series, the loading efficiency and particle size were in the order of RG504H > RG503H > RG502H. Drug release rate was decreased with the increase of the amount of PLGA feeding and initial burst was 3-10 days according to the PLGA feeding amount. At the effect of PLGA series, drug release rate was in the order of RG502H > RG503H > RG504H. When acetone was used, drug release rate was slightly increased. PLGA-coated COS microspheres were successfully prepared and characterized.

Keywords:Ciprofloxacin HCl;Low-molecular weight water-soluble chitosan;Microspheres;Multiparticulation;Sustained release

[References]

Emmerson AM, J. Chemother. 1 (Suppl. 1) (1989) 12
Appelbaum PC, Hunter PA, Int. J. Antimicrob. Agents, 16, 5 (2000)
Stratton C, Clin. Ther., 14, 348 (1992)
Davis R, Markham A, J.A. Balfour, Drugs, 51, 1019 (1996)
Naber KG, Bergman B, Bishop MC, Eur. Urol., 40, 576 (2001)
Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE, Clin. Infect. Dis., 29, 745 (1999)
Ma Z, Ma L, Gao C, Shen J, J. Control. Rel., 104, 193 (2005)
Page-Clisson ME, Pinto-Alphandary H, Ourevitch M, Andremont A, Couvreur P, J. Control. Rel., 56, 23 (1998)
Talan DA, Naber KG, Palou J, Elkharrat D, Int. J. Antimicrob. Agents, 23S1, S54 (2004)
Kim DG, Choi C, Jeong YI, Jang MK, Nah JW, J. Chitin Chitosan, 10, 192 (2005)
Jung BO, Na J, Kim CH, J. Ind. Eng. Chem., 13(5), 772 (2007)
Chae SY, Jang MK, Nah JW, J. Control. Rel., 102, 383 (2005)
Son S, Chae SY, Choi C, Kim MY, Ngugen VG, Jang MK, Nah JW, Kweon JK, Macromol. Res., 12(6), 573 (2004)
Suzuki K, Ogawa Y, Hashimoto K, Suzuki S, Suzuki M, Microbiol. Immunol., 28, 903 (1984)
Maeda Y, Kimura Y, J. Nutr., 134, 945 (2004)
Peluso G, Petillp O, Ranieri M, Santin M, Ambrosio L, Calabro D, Avallone B, Balsamo G, Biomaterials, 15, 1215 (1994)
Usami Y, Okamoto Y, Takayama T, Shigemasa Y, Minami S, J. Biomed. Mater. Res., 42, 517 (1998)
Morimoto M, Saimoto H, Usui H, Okamoto Y, Minami S, Shigemasa Y, Biomacromolecules, 2(4), 1133 (2001)
Van der Lubben IM, Verhoef JC, Van Aelst AC, Borchard G, Junginger HE, Biomaterials, 22, 687 (2001)
Sanchez AVA, Janes K, Behrens I, Kissel T, Jato JLV, Alonso MJ, Eur. J. Pharm. Biopharm., 57, 123 (2004)
Aoki T, Iskandar S, Yoshida T, Takahashi K, Hattori M, Biosci. Biotechnol. Biochem., 70, 2349 (2006)

[Referenced By]

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[1] Emmerson AM, J. Chemother. 1 (Suppl. 1) (1989) 12

[2] Appelbaum PC, Hunter PA, Int. J. Antimicrob. Agents, 16, 5 (2000)

[3] Stratton C, Clin. Ther., 14, 348 (1992)

[4] Davis R, Markham A, J.A. Balfour, Drugs, 51, 1019 (1996)

[5] Naber KG, Bergman B, Bishop MC, Eur. Urol., 40, 576 (2001)

[6] Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE, Clin. Infect. Dis., 29, 745 (1999)

[7] Ma Z, Ma L, Gao C, Shen J, J. Control. Rel., 104, 193 (2005)

[8] Page-Clisson ME, Pinto-Alphandary H, Ourevitch M, Andremont A, Couvreur P, J. Control. Rel., 56, 23 (1998)

[9] Talan DA, Naber KG, Palou J, Elkharrat D, Int. J. Antimicrob. Agents, 23S1, S54 (2004)

[10] Kim DG, Choi C, Jeong YI, Jang MK, Nah JW, J. Chitin Chitosan, 10, 192 (2005)

[11] Jung BO, Na J, Kim CH, J. Ind. Eng. Chem., 13(5), 772 (2007)

[12] Chae SY, Jang MK, Nah JW, J. Control. Rel., 102, 383 (2005)

[13] Son S, Chae SY, Choi C, Kim MY, Ngugen VG, Jang MK, Nah JW, Kweon JK, Macromol. Res., 12(6), 573 (2004)

[14] Suzuki K, Ogawa Y, Hashimoto K, Suzuki S, Suzuki M, Microbiol. Immunol., 28, 903 (1984)

[15] Maeda Y, Kimura Y, J. Nutr., 134, 945 (2004)

[16] Peluso G, Petillp O, Ranieri M, Santin M, Ambrosio L, Calabro D, Avallone B, Balsamo G, Biomaterials, 15, 1215 (1994)

[17] Usami Y, Okamoto Y, Takayama T, Shigemasa Y, Minami S, J. Biomed. Mater. Res., 42, 517 (1998)

[18] Morimoto M, Saimoto H, Usui H, Okamoto Y, Minami S, Shigemasa Y, Biomacromolecules, 2(4), 1133 (2001)

[19] Van der Lubben IM, Verhoef JC, Van Aelst AC, Borchard G, Junginger HE, Biomaterials, 22, 687 (2001)

[20] Sanchez AVA, Janes K, Behrens I, Kissel T, Jato JLV, Alonso MJ, Eur. J. Pharm. Biopharm., 57, 123 (2004)

[21] Aoki T, Iskandar S, Yoshida T, Takahashi K, Hattori M, Biosci. Biotechnol. Biochem., 70, 2349 (2006)