Preparation and Properties of Modified PHEMA Hydrogels Containing Thermo-responsive Pluronic Component

Kwang-Hyun Hong; Young-Sil Jeon; Ji-Heung Kim

Macromolecular Research, Vol.17, No.1, 26-30, January, 2009

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Preparation and Properties of Modified PHEMA Hydrogels Containing Thermo-responsive Pluronic Component

Kwang-Hyun Hong, Young-Sil Jeon, and Ji-Heung Kim^†

Department of Chemical Engineering, Polymer Technology Institute, Sungkyunkwan University, Gyeonggi 440-746, Korea

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To modify and strengthen the properties of PHEMA hydrogel, composite hydrogels containing varying amounts of a Pluronic (PEO-PPO-PEO) component were synthesized by bulk polymerization of HEMA in the presence of Pluronic dimethacrylate under mild photoinitiating conditions. The effects of the Pluronic component on gel properties were investigated by measuring the degree of swelling with its temperature responsive behavior, the mechanical properties, and the morphology of the composite hydrogels. With increased Pluronic content, the modified PHEMA hydrogels exhibited an increase in the degree of swelling, and the swelling showed an enhanced thermo-responsive behavior that was completely reversible. In addition, improved mechanical strength and the development of a microporous gel morphology were observed in hydrogels containing Pluronic.

Keywords:PHEMA;Pluronic F127;thermo-responsive swelling;photo-polymerization.

[References]

Ratner BD, Hoffman AS, Schoen FJ, Lemons JE, Eds., Biomaterials Science, 2nd Ed., Elsevier Academic Press, UK, 2004
Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 255 (1990)
Kim MR, Park TG, J. Control. Release, 80, 69 (2002)
Ankareddi I, Brazel CS, Inter. J. Pharm., 336, 241 (2007)
Ruel-Gariepy E, Leroux JC, Eur. J. Pharm. Biopharm., 58, 409 (2004)
Cohn D, Lando G, Sosnik A, Garty S, Levi A, Biomaterials, 27, 1718 (2006)
Khare AR, Peppas NA, Biomaterials, 16, 559 (1995)
Determan MD, Cox JP, Mallapragada SK, Journal of Biomaterials Research Part A, 81A, 326 (2007)
Halpenny GM, Olmstead MM, Mascharak PK, Inorg. Chem., 46(16), 6601 (2007)
He H, Cao X, Lee LJ, J. Control. Release, 95, 391 (2004)
Chiappetta DA, Sosnik A, Eur. J. Pharm. Biopharm., 66, 303 (2007)
Drury JL, Mooney DJ, Biomaterials, 24, 4337 (2003)
Von Recum HA, Kim SW, Kikuchi A, Okuhara M, Sakurai Y, Okano T, J. Biomed. Mater. Res., 40, 631 (1998)
Chung HJ, Lee Y, Park TG, J. Control. Release, 127, 22 (2008)
Li CC, Abrahamson M, Kapoor Y, Chauhan A, J. Colloid Interface Sci., 315(1), 297 (2007)
David G, Simionescu BC, Albertsson AC, Biomacromolecules, 9, 1678 (2008)
Ayhan F, Ozkan S, Drug Deliv., 14, 433 (2007)
Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)
Jung YP, Son YK, Kim JH, Macromol. Res., 15(1), 82 (2007)
Jung YP, Kim JH, Lee DS, Kim YH, J. Appl. Polym. Sci., 104(4), 2484 (2007)
Sosnik AS, Cohn D, Roman JS, Abraham GA, J. Biomater. Sci. Polym. Ed., 14, 227 (2003)
Yin L, Fei L, Tang C, Yin C, Polym. Int., 56, 1563 (2007)

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[2] Okano T, Bae YH, Jacobs H, Kim SW, J. Control. Release, 11, 255 (1990)

[3] Kim MR, Park TG, J. Control. Release, 80, 69 (2002)

[4] Ankareddi I, Brazel CS, Inter. J. Pharm., 336, 241 (2007)

[5] Ruel-Gariepy E, Leroux JC, Eur. J. Pharm. Biopharm., 58, 409 (2004)

[6] Cohn D, Lando G, Sosnik A, Garty S, Levi A, Biomaterials, 27, 1718 (2006)

[7] Khare AR, Peppas NA, Biomaterials, 16, 559 (1995)

[8] Determan MD, Cox JP, Mallapragada SK, Journal of Biomaterials Research Part A, 81A, 326 (2007)

[9] Halpenny GM, Olmstead MM, Mascharak PK, Inorg. Chem., 46(16), 6601 (2007)

[10] He H, Cao X, Lee LJ, J. Control. Release, 95, 391 (2004)

[11] Chiappetta DA, Sosnik A, Eur. J. Pharm. Biopharm., 66, 303 (2007)

[12] Drury JL, Mooney DJ, Biomaterials, 24, 4337 (2003)

[13] Von Recum HA, Kim SW, Kikuchi A, Okuhara M, Sakurai Y, Okano T, J. Biomed. Mater. Res., 40, 631 (1998)

[14] Chung HJ, Lee Y, Park TG, J. Control. Release, 127, 22 (2008)

[15] Li CC, Abrahamson M, Kapoor Y, Chauhan A, J. Colloid Interface Sci., 315(1), 297 (2007)

[16] David G, Simionescu BC, Albertsson AC, Biomacromolecules, 9, 1678 (2008)

[17] Ayhan F, Ozkan S, Drug Deliv., 14, 433 (2007)

[18] Son YK, Jung YP, Kim JH, Chung DJ, Macromol. Res., 14(3), 394 (2006)

[19] Jung YP, Son YK, Kim JH, Macromol. Res., 15(1), 82 (2007)

[20] Jung YP, Kim JH, Lee DS, Kim YH, J. Appl. Polym. Sci., 104(4), 2484 (2007)

[21] Sosnik AS, Cohn D, Roman JS, Abraham GA, J. Biomater. Sci. Polym. Ed., 14, 227 (2003)

[22] Yin L, Fei L, Tang C, Yin C, Polym. Int., 56, 1563 (2007)